HNRNPA1 Antibody
| Code | Size | Price |
|---|
| PSI-58-858-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Heterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, HNRNPA1, HNRPA1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene belongs to the A/B subfamily of ubiquitously
expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
hnRNPs are RNA binding proteins and they complex with heterogeneous
nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs
in the nucleus and appear to influence pre-mRNA processing and
other aspects of mRNA metabolism and transport. While all of the
hnRNPs are present in the nucleus, some seem to shuttle between the
nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic
acid binding properties. The protein encoded by this gene has two
repeats of quasi-RRM domains that bind to RNAs. It is one of the
most abundant core proteins of hnRNP complexes and it is localized
to the nucleoplasm. This protein, along with other hnRNP proteins,
is exported from the nucleus, probably bound to mRNA, and is
immediately re-imported. Its M9 domain acts as both a nuclear
localization and nuclear export signal. The encoded protein is
involved in the packaging of pre-mRNA into hnRNP particles,
transport of poly A+ mRNA from the nucleus to the cytoplasm, and
may modulate splice site selection. It is also thought have a
primary role in the formation of specific myometrial protein
species in parturition. Multiple alternatively spliced transcript
variants have been found for this gene but only two transcripts are
fully described. These variants have multiple alternative
transcription initiation sites and multiple polyA sites. [provided
by RefSeq].
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Michlewski, G., et al. Nat. Struct. Mol. Biol. 17(8):1011-1018(2010)
- Clower, C.V., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):1894-1899(2010)
- David, C.J., et al. Nature 463(7279):364-368(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HNRNPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-294 amino acids from the C-terminal region of human HNRNPA1.
NCBI Gene ID #:
3178
NCBI Official Name:
Heterogeneous nuclear ribonucleoprotein A1
NCBI Official Symbol:
HNRNPA1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
39 kDa
Protein Accession #:
P09651
Protein GI Number:
288558857
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P09651
User NOte:
Optimal dilutions for each application to be determined by the researcher.