RPL10 Antibody
| Code | Size | Price |
|---|
| PSI-60-292-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
60S ribosomal protein L10, Laminin receptor homolog, Protein QM, Tumor suppressor QM, RPL10, DXS648E, QM
Application Note:
For WB starting dilution is: 1:1000
Background:
Ribosomes, the organelles that catalyze protein synthesis,
consist of a small 40S subunit and a large 60S subunit. Together
these subunits are composed of 4 RNA species and approximately 80
structurally distinct proteins. This gene encodes a ribosomal
protein that is a component of the 60S subunit. The protein belongs
to the L10E family of ribosomal proteins. It is located in the
cytoplasm. In vitro studies have shown that the chicken protein can
bind to c-Jun and can repress c-Jun-mediated transcriptional
activation, but these activities have not been demonstrated in
vivo. This gene was initially identified as a candidate for a Wilms
tumor suppressor gene, but later studies determined that this gene
is not involved in the suppression of Wilms tumor. This gene has
been referred to as 'laminin receptor homolog' because a chimeric
transcript consisting of sequence from this gene and sequence from
the laminin receptor gene was isolated; however, it is not believed
that this gene encodes a laminin receptor. Transcript variants
utilizing alternative polyA signals exist. The variant with the
longest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on the
opposite strand. This gene is co-transcribed with the small
nucleolar RNA gene U70, which is located in its fifth intron. As is
typical for genes encoding ribosomal proteins, there are multiple
processed pseudogenes of this gene dispersed through the genome.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Gong, X., et al. BMC Med. Genet. 10,(2009) :
- Nishimura, M., et al. J. Mol. Biol. 377(2):421-430(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Chicken, Pig, Rat
Immunogen:
This RPL10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human RPL10.
NCBI Gene ID #:
6134
NCBI Official Name:
60S ribosomal protein L10
NCBI Official Symbol:
RPL10
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
25 kDa
Protein Accession #:
P27635
Protein GI Number:
148887414
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P27635
User NOte:
Optimal dilutions for each application to be determined by the researcher.