TAF10 Antibody
| Code | Size | Price |
|---|
| PSI-60-151-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Transcription initiation factor TFIID subunit 10, STAF28, Transcription initiation factor TFIID 30 kDa subunit, TAF(II)30, TAFII-30, TAFII30, TAF10, TAF2A, TAF2H, TAFII30
Application Note:
For WB starting dilution is: 1:1000
Background:
Initiation of transcription by RNA polymerase II requires
the activities of more than 70 polypeptides. The protein that
coordinates these activities is transcription factor IID (TFIID),
which binds to the core promoter to position the polymerase
properly, serves as the scaffold for assembly of the remainder of
the transcription complex, and acts as a channel for regulatory
signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated
factors or TAFs. TAFs may participate in basal transcription, serve
as coactivators, function in promoter recognition or modify general
transcription factors (GTFs) to facilitate complex assembly and
transcription initiation. This gene encodes one of the small
subunits of TFIID that is associated with a subset of TFIID
complexes. Studies with human and mammalian cells have shown that
this subunit is required for transcriptional activation by the
estrogen receptor, for progression through the cell cycle, and may
also be required for certain cellular differentiation programs.
Background References:
- Egloff, S., et al. J. Biol. Chem. 285(27):20564-20569(2010)
- Ma, Y., et al. J. Biol. Chem. 285(13):9813-9822(2010)
- Zhao, Y., et al. Mol. Cell 29(1):92-101(2008)
- Hao, H., et al. Oncogene 26(57):7872-7884(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This TAF10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-150 amino acids from the Central region of human TAF10.
NCBI Gene ID #:
6881
NCBI Official Name:
Transcription initiation factor TFIID subunit 10
NCBI Official Symbol:
TAF10
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
22 kDa
Protein Accession #:
Q12962
Protein GI Number:
3024688
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q12962
User NOte:
Optimal dilutions for each application to be determined by the researcher.