HUS1 Antibody
| Code | Size | Price |
|---|
| PSI-58-806-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Checkpoint protein HUS1, hHUS1, HUS1
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a component of an
evolutionarily conserved, genotoxin-activated checkpoint complex
that is involved in the cell cycle arrest in response to DNA
damage. This protein forms a heterotrimeric complex with checkpoint
proteins RAD9 and RAD1. In response to DNA damage, the trimeric
complex interacts with another protein complex consisting of
checkpoint protein RAD17 and four small subunits of the replication
factor C (RFC), which loads the combined complex onto the
chromatin. The DNA damage induced chromatin binding has been shown
to depend on the activation of the checkpoint kinase ATM, and is
thought to be an early checkpoint signaling event. [provided by
RefSeq].
Background References:
- Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
- Takeishi, Y., et al. Genes Cells 15(7):761-771(2010)
- Bai, H., et al. DNA Repair (Amst.) 9(5):478-487(2010)
- Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HUS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-226 amino acids from the C-terminal region of human HUS1.
NCBI Gene ID #:
3364
NCBI Official Name:
Checkpoint protein HUS1
NCBI Official Symbol:
HUS1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
32 kDa
Protein Accession #:
O60921
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
O60921
User NOte:
Optimal dilutions for each application to be determined by the researcher.