TAF6 Antibody
| Code | Size | Price |
|---|
| PSI-57-846-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Transcription initiation factor TFIID subunit 6, RNA polymerase II TBP-associated factor subunit E, Transcription initiation factor TFIID 70 kDa subunit, TAF(II)70, TAFII-70, TAFII70, Transcription initiation factor TFIID 80 kDa subunit, TAF(II)80, TAFII-80, TAFII80, TAF6, TAF2E, TAFII70
Application Note:
For WB starting dilution is: 1:1000
Background:
Initiation of transcription by RNA polymerase II requires
the activities of more than 70 polypeptides. The protein that
coordinates these activities is transcription factor IID (TFIID),
which binds to the core promoter to position the polymerase
properly, serves as the scaffold for assembly of the remainder of
the transcription complex, and acts as a channel for regulatory
signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated
factors or TAFs. TAFs may participate in basal transcription, serve
as coactivators, function in promoter recognition or modify general
transcription factors (GTFs) to facilitate complex assembly and
transcription initiation. This gene encodes one of the smaller
subunits of TFIID that binds weakly to TBP but strongly to TAF1,
the largest subunit of TFIID. Alternative splicing results in
multiple transcript variants.
Background References:
- Theisen, J.W., et al. Mol. Cell. Biol. (2010) In press :
- Wilhelm, E., et al. BMC Mol. Biol. 11, 10 (2010) :
- Wilhelm, E., et al. PLoS ONE(7), E2721 (2008) :
- Frontini, M., et al. Mol. Cell. Biol. 25(11):4638-4649(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This TAF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human TAF6.
NCBI Gene ID #:
6878
NCBI Official Name:
Transcription initiation factor TFIID subunit 6
NCBI Official Symbol:
TAF6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
73 kDa
Protein Accession #:
P49848
Protein GI Number:
1729810
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P49848
User NOte:
Optimal dilutions for each application to be determined by the researcher.