WRN Antibody
| Code | Size | Price |
|---|
| PSI-56-216-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Werner syndrome ATP-dependent helicase, DNA helicase, RecQ-like type 3, RecQ3, Exonuclease WRN, 31--, RecQ protein-like 2, WRN, RECQ3, RECQL2
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
This gene encodes a member of the RecQ subfamily and the
DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA
helicases are involved in many aspects of DNA metabolism, including
transcription, replication, recombination, and repair. This protein
contains a nuclear localization signal in the C-terminus and shows
a predominant nucleolar localization. It possesses an intrinsic 3'
to 5' DNA helicase activity, and is also a 3' to 5' exonuclease.
Based on interactions between this protein and Ku70/80 heterodimer
in DNA end processing, this protein may be involved in the repair
of double strand DNA breaks. Defects in this gene are the cause of
Werner syndrome, an autosomal recessive disorder characterized by
premature aging.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Perry, J.J., et al. J. Biol. Chem. 285(33):25699-25707(2010)
- Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)
- Kobayashi, J., et al. Mech. Ageing Dev. 131(6):436-444(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This WRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 787-816 amino acids from the Central region of human WRN.
NCBI Gene ID #:
7486
NCBI Official Name:
Werner syndrome ATP-dependent helicase
NCBI Official Symbol:
WRN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
162 kDa
Protein Accession #:
Q14191
Protein GI Number:
322510082
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q14191
User NOte:
Optimal dilutions for each application to be determined by the researcher.