EWSR1 Antibody
| Code | Size | Price |
|---|
| PSI-57-829-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWSR1, EWS
Application Note:
For WB starting dilution is: 1:1000
For IF starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
Background:
This gene encodes a multifunctional protein that is
involved in various cellular processes, including gene expression,
cell signaling, and RNA processing and transport. The protein
includes an N-terminal transcriptional activation domain and a
C-terminal RNA-binding domain. Chromosomal translocations between
this gene and various genes encoding transcription factors result
in the production of chimeric proteins that are involved in
tumorigenesis. These chimeric proteins usually consist of the
N-terminal transcriptional activation domain of this protein fused
to the C-terminal DNA-binding domain of the transcription factor
protein. Mutations in this gene, specifically a t(11;22)(q24;q12)
translocation, are known to cause Ewing sarcoma as well as
neuroectodermal and various other tumors. Alternative splicing of
this gene results in multiple transcript variants. Related
pseudogenes have been identified on chromosomes 1 and 14. [provided
by RefSeq].
Background References:
- Lagirand-Cantaloube, J., et al. Biochem. Biophys. Res. Commun. 399(4):705-710(2010)
- Kumagai, A., et al. Am. J. Clin. Pathol. 134(2):323-331(2010)
- Aryee, D.N., et al. Cancer Res. 70(10):4015-4023(2010)
- Riggi, N., et al. Genes Dev. 24(9):916-932(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This EWSR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 623-652 amino acids from the C-terminal region of human EWSR1.
NCBI Gene ID #:
2130
NCBI Official Name:
RNA-binding protein EWS
NCBI Official Symbol:
EWSR1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
68 kDa
Protein Accession #:
Q01844
Protein GI Number:
544261
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q01844
User NOte:
Optimal dilutions for each application to be determined by the researcher.