CAF-1 Antibody
| Code | Size | Price |
|---|
| PSI-55-638-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
CCR4-NOT transcription complex subunit 7, BTG1-binding factor 1, CCR4-associated factor 1, CAF-1, Caf1a, CNOT7, CAF1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IF starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For IF starting dilution is: 1:10~50
Background:
The protein encoded by this gene binds to an
anti-proliferative protein, B-cell translocation protein 1, which
negatively regulates cell proliferation. Binding of the two
proteins, which is driven by phosphorylation of the
anti-proliferative protein, causes signaling events in cell
division that lead to changes in cell proliferation associated with
cell-cell contact. The protein has both mouse and yeast orthologs.
Alternate splicing of this gene results in two transcript variants
encoding different isoforms.
Background References:
- Lau, N.C., et al. Biochem. J. 422(3):443-453(2009)
- Aslam, A., et al. Mol. Biol. Cell 20(17):3840-3850(2009)
- Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)
- Nishida, K., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 63 (PT 12), 1061-1063 (2007) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, Mouse, Xenopus
Immunogen:
This CAF-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-61 amino acids from the N-terminal region of human CAF-1.
NCBI Gene ID #:
29883
NCBI Official Name:
CCR4-NOT transcription complex subunit 7
NCBI Official Symbol:
CNOT7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
33 kDa
Protein Accession #:
Q9UIV1
Protein GI Number:
41713629
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9UIV1
User NOte:
Optimal dilutions for each application to be determined by the researcher.