ATF4 Antibody
| Code | Size | Price |
|---|
| PSI-56-296-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Cyclic AMP-dependent transcription factor ATF-4, cAMP-dependent transcription factor ATF-4, Activating transcription factor 4, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, Tax-responsive enhancer element-binding protein 67, TaxREB67, ATF4, CREB2, TXREB
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a transcription factor that was
originally identified as a widely expressed mammalian DNA binding
protein that could bind a tax-responsive enhancer element in the
LTR of HTLV-1. The encoded protein was also isolated and
characterized as the cAMP-response element binding protein 2
(CREB-2). The protein encoded by this gene belongs to a family of
DNA-binding proteins that includes the AP-1 family of transcription
factors, cAMP-response element binding proteins (CREBs) and
CREB-like proteins. These transcription factors share a leucine
zipper region that is involved in protein-protein interactions,
located C-terminal to a stretch of basic amino acids that functions
as a DNA binding domain. Two alternative transcripts encoding the
same protein have been described. Two pseudogenes are located on
the X chromsome at q28 in a region containing a large inverted
duplication.
Background References:
- Dey, S., et al. J. Biol. Chem. 285(43):33165-33174(2010)
- Frank, C.L., et al. J. Biol. Chem. 285(43):33324-33337(2010)
- Rzymski, T., et al. Oncogene 29(31):4424-4435(2010)
- Liew, C.W., et al. J. Clin. Invest. 120(8):2876-2888(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ATF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-198 amino acids from the Central region of human ATF4.
NCBI Gene ID #:
468
NCBI Official Name:
Cyclic AMP-dependent transcription factor ATF-4
NCBI Official Symbol:
ATF4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
39 kDa
Protein Accession #:
P18848
Protein GI Number:
116241262
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P18848
User NOte:
Optimal dilutions for each application to be determined by the researcher.