SAFB Antibody
| Code | Size | Price |
|---|
| PSI-59-146-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Scaffold attachment factor B1, SAF-B, SAF-B1, HSP27 estrogen response element-TATA box-binding protein, HSP27 ERE-TATA-binding protein, SAFB, HAP, HET, SAFB1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a DNA-binding protein that has high
specificity for scaffold or matrix attachment region DNA elements
(S/MAR DNA). This protein is thought to be involved in attaching
the base of chromatin loops to the nuclear matrix but there is
conflicting evidence as to whether this protein is a component of
chromatin or a nuclear matrix protein. Scaffold attachment factors
are a specific subset of nuclear matrix proteins (NMP) that
specifically bind to S/MAR. This encoded protein is thought to
serve as a molecular base to assemble a 'transcriptosome complex'
in the vicinity of actively transcribed genes. It is involved in
the regulation of the heat shock protein 27 transcription and also
can act as an estrogen receptor corepressor. This gene is a
candidate gene for breast tumorigenesis.
Background References:
- Hammerich-Hille, S., et al. Breast Cancer Res. Treat. 121(2):503-509(2010)
- Hammerich-Hille, S., et al. J. Biol. Chem. 285(6):3608-3616(2010)
- Tsianou, D., et al. FEBS J. 276(18):5212-5227(2009)
- Chen, H., et al. Endocrinology 150(5):2429-2435(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SAFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-94 amino acids from the N-terminal region of human SAFB.
NCBI Gene ID #:
6294
NCBI Official Name:
Scaffold attachment factor B1
NCBI Official Symbol:
SAFB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
103 kDa
Protein Accession #:
Q15424
Protein GI Number:
116242782
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q15424
User NOte:
Optimal dilutions for each application to be determined by the researcher.