PUF60 Antibody
| Code | Size | Price |
|---|
| PSI-57-685-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Poly(U)-binding-splicing factor PUF60, 60 kDa poly(U)-binding-splicing factor, FUSE-binding protein-interacting repressor, FBP-interacting repressor, Ro-binding protein 1, RoBP1, Siah-binding protein 1, Siah-BP1, PUF60, FIR, ROBPI, SIAHBP1
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a Ro RNP-binding
protein. It interacts with Ro RNPs and their interaction is thought
to represent a gain of function for Ro RNPs. This protein also
forms a ternary complex with far upstream element (FUSE) and
FUSE-binding protein. It can repress a c-myc reporter via the FUSE.
It is also known to target transcription factor IIH and inhibit
activated transcription. This gene is implicated in the xeroderma
pigmentosum disorder. There are two alternatively spliced
transcript variants of this gene encoding different isoforms. There
seems to be evidence of multiple polyadenylation sites for this
gene.
Background References:
- Hsiao, H.H., et al. Biochemistry 49(22):4620-4634(2010)
- Corsini, L., et al. J. Biol. Chem. 284(1):630-639(2009)
- Gao, J., et al. Genomics 91(4):347-355(2008)
- Hastings, M.L., et al. PLoS ONE(6), E538 (2007) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PUF60 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-43 amino acids from the N-terminal region of human PUF60.
NCBI Gene ID #:
22827
NCBI Official Name:
Poly(U)-binding-splicing factor PUF60
NCBI Official Symbol:
PUF60
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
Q9UHX1
Protein GI Number:
74761960
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9UHX1
User NOte:
Optimal dilutions for each application to be determined by the researcher.