TCEB2 Antibody
| Code | Size | Price |
|---|
| PSI-57-645-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Transcription elongation factor B polypeptide 2, Elongin 18 kDa subunit, Elongin-B, EloB, RNA polymerase II transcription factor SIII subunit B, SIII p18, TCEB2
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes the protein elongin B, which is a
subunit of the transcription factor B (SIII) complex. The SIII
complex is composed of elongins A/A2, B and C. It activates
elongation by RNA polymerase II by suppressing transient pausing of
the polymerase at many sites within transcription units. Elongin A
functions as the transcriptionally active component of the SIII
complex, whereas elongins B and C are regulatory subunits. Elongin
A2 is specifically expressed in the testis, and capable of forming
a stable complex with elongins B and C. The von Hippel-Lindau tumor
suppressor protein binds to elongins B and C, and thereby inhibits
transcription elongation. Two alternatively spliced transcript
variants encoding different isoforms have been described for this
gene. Pseudogenes have been identified on chromosomes 11 and 13.
Background References:
- Marcsisin, S.R., et al. J. Mol. Biol. 402(5):892-904(2010)
- Piessevaux, J., et al. J. Biol. Chem. 283(31):21334-21346(2008)
- Van Herreweghe, E., et al. EMBO J. 26(15):3570-3580(2007)
- Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TCEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-48 amino acids from the Central region of human TCEB2.
NCBI Gene ID #:
6923
NCBI Official Name:
Transcription elongation factor B polypeptide 2
NCBI Official Symbol:
TCEB2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
13 kDa
Protein Accession #:
Q15370
Protein GI Number:
32699512
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q15370
User NOte:
Optimal dilutions for each application to be determined by the researcher.