WHSC2 Antibody
| Code | Size | Price |
|---|
| PSI-57-999-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Negative elongation factor A, NELF-A, Wolf-Hirschhorn syndrome candidate 2 protein, NELFA, WHSC2
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene is expressed ubiquitously with higher levels in
fetal than in adult tissues. It encodes a protein sharing 93%
sequence identity with the mouse protein. Wolf-Hirschhorn syndrome
(WHS) is a malformation syndrome associated with a hemizygous
deletion of the distal short arm of chromosome 4. This gene is
mapped to the 165 kb WHS critical region, and may play a role in
the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded
protein is found to be capable of reacting with HLA-A2-restricted
and tumor-specific cytotoxic T lymphocytes, suggesting a target for
use in specific immunotherapy for a large number of cancer
patients. This protein has also been shown to be a member of the
NELF (negative elongation factor) protein complex that participates
in the regulation of RNA polymerase II transcription elongation.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Narita, T., et al. Mol. Cell 26(3):349-365(2007)
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
- Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This WHSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the Central region of human WHSC2.
NCBI Gene ID #:
7469
NCBI Official Name:
Negative elongation factor A
NCBI Official Symbol:
NELFA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Protein Accession #:
Q9H3P2
Protein GI Number:
212276499
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9H3P2
User NOte:
Optimal dilutions for each application to be determined by the researcher.