COBRA1 Antibody
| Code | Size | Price |
|---|
| PSI-57-973-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Negative elongation factor B, NELF-B, Cofactor of BRCA1, NELFB, COBRA1, KIAA1182
Application Note:
For WB starting dilution is: 1:1000
Background:
NELFB is a subunit of negative elongation factor (NELF),
which also includes NELFA (WHSC2; MIM 606026), either NELFC or
NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts
with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4
(SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause
transcriptional pausing of RNA polymerase II (see MIM 180660)
(Narita et al., 2003 [PubMed 12612062]).
Background References:
- Sun, J., et al. J. Cell. Biochem. 103(6):1798-1807(2008)
- Sun, J., et al. J. Steroid Biochem. Mol. Biol. 107 (3-5), 131-139 (2007) :
- Wu, C., et al. Proteomics 7(11):1775-1785(2007)
- Narita, T., et al. Mol. Cell 26(3):349-365(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This COBRA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-285 amino acids from the Central region of human COBRA1.
NCBI Gene ID #:
25920
NCBI Official Name:
Negative elongation factor B
NCBI Official Symbol:
NELFB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
66 kDa
Protein Accession #:
Q8WX92
Protein GI Number:
38372378
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q8WX92
User NOte:
Optimal dilutions for each application to be determined by the researcher.