LIG3 Antibody
| Code | Size | Price |
|---|
| PSI-58-255-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA ligase 3, DNA ligase III, Polydeoxyribonucleotide synthase [ATP] 3, LIG3
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene is a member of the DNA ligase family. Each
member of this family encodes a protein that catalyzes the joining
of DNA ends but they each have a distinct role in DNA metabolism.
The protein encoded by this gene is involved in excision repair and
is located in both the mitochondria and nucleus, with translation
initiation from the upstream start codon allowing for transport to
the mitochondria and translation initiation from a downstream start
codon allowing for transport to the nucleus. Additionally,
alternate transcriptional splice variants, encoding different
isoforms, have been characterized.
Background References:
- Wang, W., et al. Nucleic Acids Res. (2010) In press :
- Arora, M., et al. Leukemia 24(8):1470-1475(2010)
- Cotner-Gohara, E., et al. Biochemistry 49(29):6165-6176(2010)
- Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This LIG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 793-822 amino acids from the C-terminal region of human LIG3.
NCBI Gene ID #:
3980
NCBI Official Name:
DNA ligase 3
NCBI Official Symbol:
LIG3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
113 kDa
Protein Accession #:
P49916
Protein GI Number:
251757259
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P49916
User NOte:
Optimal dilutions for each application to be determined by the researcher.