NEIL2 Antibody

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ProSci
Product Code: PSI-58-223
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-58-223-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in HepG2 cell line lysates (35ug/lane).
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Western blot analysis in HepG2 cell line lysates (35ug/lane).

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Further Information

Additional Names:
Endonuclease 8-like 2, 322-, DNA glycosylase/AP lyase Neil2, DNA-(apurinic or apyrimidinic site) lyase Neil2, Endonuclease VIII-like 2, Nei homolog 2, NEH2, Nei-like protein 2, NEIL2
Application Note:
For WB starting dilution is: 1:1000
Background:
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])
Background References:
  • Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)
  • Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :
  • Grin, I.R., et al. Biochem. Biophys. Res. Commun. 394(1):100-105(2010)
  • Kinslow, C.J., et al. Genes Chromosomes Cancer 47(11):923-932(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This NEIL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human NEIL2.
NCBI Gene ID #:
252969
NCBI Official Name:
Endonuclease 8-like 2
NCBI Official Symbol:
NEIL2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
37 kDa
Protein Accession #:
Q969S2
Protein GI Number:
56404653
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q969S2
User NOte:
Optimal dilutions for each application to be determined by the researcher.