TTL Antibody
| Code | Size | Price |
|---|
| PSI-58-579-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Tubulin--tyrosine ligase, TTL, TTL
Application Note:
For WB starting dilution is: 1:1000
Background:
TTL is a cytosolic enzyme involved in the
posttranslational modification of alpha-tubulin (see MIM 602529).
Alpha-tubulin within assembled microtubules is detyrosinated over
time at the C terminus. After microtubule disassembly, TTL restores
the tyrosine residues and consequently participates in a cycle of
tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed
14571137]).
Background References:
- Dick, D.M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
- Erck, C., et al. Cytogenet. Genome Res. 101(1):47-53(2003)
- Mialhe, A., et al. Cancer Res. 61(13):5024-5027(2001)
- Ersfeld, K., et al. J. Cell Biol. 120(3):725-732(1993)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rat
Immunogen:
This TTL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-263 amino acids from the C-terminal region of human TTL.
NCBI Gene ID #:
150465
NCBI Official Name:
Tubulin--tyrosine ligase
NCBI Official Symbol:
TTL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
43 kDa
Protein Accession #:
Q8NG68
Protein GI Number:
47117358
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q8NG68
User NOte:
Optimal dilutions for each application to be determined by the researcher.