MCM7 Antibody
| Code | Size | Price |
|---|
| PSI-58-402-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA replication licensing factor MCM7, CDC47 homolog, P11-MCM3, MCM7, CDC47, MCM2
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is one of the highly
conserved mini-chromosome maintenance proteins (MCM) that are
essential for the initiation of eukaryotic genome replication. The
hexameric protein complex formed by the MCM proteins is a key
component of the pre-replication complex (pre_RC) and may be
involved in the formation of replication forks and in the
recruitment of other DNA replication related proteins. The MCM
complex consisting of this protein and MCM2, 4 and 6 proteins
possesses DNA helicase activity, and may act as a DNA unwinding
enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate
with this protein, and may regulate the binding of this protein
with the tumorsuppressor protein RB1/RB. Alternatively spliced
transcript variants encoding distinct isoforms have been reported.
Background References:
- Lau, K.M., et al. Oncogene 29(40):5475-5489(2010)
- Kim, D.W., et al. Mol. Biochem. Parasitol. 173(1):10-16(2010)
- Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
- Rojiani, M.V., et al. Appl. Immunohistochem. Mol. Morphol. 18(3):278-282(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MCM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-318 amino acids from the N-terminal region of human MCM7.
NCBI Gene ID #:
4176
NCBI Official Name:
DNA replication licensing factor MCM7
NCBI Official Symbol:
MCM7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
81 kDa
Protein Accession #:
P33993
Protein GI Number:
20981696
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P33993
User NOte:
Optimal dilutions for each application to be determined by the researcher.