MCM3 Antibody
| Code | Size | Price |
|---|
| PSI-57-424-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, RLF subunit beta, p102, MCM3
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is one of the highly
conserved mini-chromosome maintenance proteins (MCM) that are
involved in the initiation of eukaryotic genome replication. The
hexameric protein complex formed by MCM proteins is a key component
of the pre-replication complex (pre_RC) and may be involved in the
formation of replication forks and in the recruitment of other DNA
replication related proteins. This protein is a subunit of the
protein complex that consists of MCM2-7. It has been shown to
interact directly with MCM5/CDC46. This protein also interacts
with, and thus is acetlyated by MCM3AP, a chromatin-associated
acetyltransferase. The acetylation of this protein inhibits the
initiation of DNA replication and cell cycle progression. [provided
by RefSeq].
Background References:
- Lau, K.M., et al. Oncogene 29(40):5475-5489(2010)
- Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
- Lee, Y.S., et al. Exp. Mol. Pathol. 88(1):138-142(2010)
- Song, Y.J., et al. Acta Virol. 54(2):125-130(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This MCM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human MCM3.
NCBI Gene ID #:
4172
NCBI Official Name:
DNA replication licensing factor MCM3
NCBI Official Symbol:
MCM3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
91 kDa
Protein Accession #:
P25205
Protein GI Number:
19857543
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P25205
User NOte:
Optimal dilutions for each application to be determined by the researcher.