RRM1 Antibody
| Code | Size | Price |
|---|
| PSI-60-858-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes one of two non-identical subunits that
constitute ribonucleoside-diphosphate reductase, an enzyme
essential for the production of deoxyribonucleotides prior to DNA
synthesis in S phase of dividing cells. It is one of several genes
located in the imprinted gene domain of 11p15.5, an important
tumor-suppressor gene region. Alterations in this region have been
associated with the Beckwith-Wiedemann syndrome, Wilms tumor,
rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and
breast cancer. This gene may play a role in malignancies and
disease that involve this region.
Background References:
- Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
- Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
- Vinolas, N., et al. Lung Cancer (2010) In press :
- Niida, H., et al. Genes Dev. 24(4):333-338(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This RRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human RRM1.
NCBI Gene ID #:
6240
NCBI Official Name:
Ribonucleoside-diphosphate reductase large subunit
NCBI Official Symbol:
RRM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
90 kDa
Protein Accession #:
P23921
Protein GI Number:
132608
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P23921
User NOte:
Optimal dilutions for each application to be determined by the researcher.