FANCL Antibody
| Code | Size | Price |
|---|
| PSI-60-582-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
E3 ubiquitin-protein ligase FANCL, 632-, Fanconi anemia group L protein, Fanconi anemia-associated polypeptide of 43 kDa, FAAP43, FANCL, PHF9
Application Note:
For WB starting dilution is: 1:1000
Background:
The Fanconi anemia complementation group (FANC) currently
includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2,
FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM
and FANCN (also called PALB2). The previously defined group FANCH
is the same as FANCA. Fanconi anemia is a genetically heterogeneous
recessive disorder characterized by cytogenetic instability,
hypersensitivity to DNA crosslinking agents, increased chromosomal
breakage, and defective DNA repair. The members of the Fanconi
anemia complementation group do not share sequence similarity; they
are related by their assembly into a common nuclear protein
complex. This gene encodes the protein for complementation group L.
Alternative splicing results in two transcript variants encoding
different isoforms.
Background References:
- Zhang, J., et al. J. Clin. Invest. 120(5):1524-1534(2010)
- Garcia, M.J., et al. Carcinogenesis 30(11):1898-1902(2009)
- McWilliams, R.R., et al. Cancer Epidemiol. Biomarkers Prev. 18(9):2549-2552(2009)
- Longerich, S., et al. J. Biol. Chem. 284(35):23182-23186(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FANCL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-302 amino acids from the C-terminal region of human FANCL.
NCBI Gene ID #:
55120
NCBI Official Name:
E3 ubiquitin-protein ligase FANCL
NCBI Official Symbol:
FANCL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
43 kDa
Protein Accession #:
Q9NW38
Protein GI Number:
116241360
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9NW38
User NOte:
Optimal dilutions for each application to be determined by the researcher.