RAD51C Antibody
| Code | Size | Price |
|---|
| PSI-58-132-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA repair protein RAD51 homolog 3, R51H3, RAD51 homolog C, RAD51-like protein 2, RAD51C, RAD51L2
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene is a member of the RAD51 family of related
genes, which encode strand-transfer proteins thought to be involved
in recombinational repair of damaged DNA and in meiotic
recombination. This gene product interacts with two other DNA
repair proteins, encoded by RAD51B and XRCC3, but not with itself.
The protein copurifies with XRCC3 protein in a complex, reflecting
their endogenous association and suggesting a cooperative role
during recombinational repair. This gene is one of four localized
to a region of chromosome 17q23 where amplification occurs
frequently in breast tumors. Overexpression of the four genes
during amplification has been observed and suggests a possible role
in tumor progression. Alternative splicing has been observed for
this gene and two variants encoding different isoforms have been
identified.
Background References:
- Zheng, Y., et al. Breast Cancer Res. Treat. (2010) In press :
- Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)
- Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :
- Meindl, A., et al. Nat. Genet. 42(5):410-414(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RAD51C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-198 amino acids from the Central region of human RAD51C.
NCBI Gene ID #:
5889
NCBI Official Name:
DNA repair protein RAD51 homolog 3
NCBI Official Symbol:
RAD51C
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
Protein Accession #:
O43502
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
O43502
User NOte:
Optimal dilutions for each application to be determined by the researcher.