PABPN1 Antibody
| Code | Size | Price |
|---|
| PSI-58-751-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Polyadenylate-binding protein 2, PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1, PABPN1, PAB2, PABP2
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes an abundant nuclear protein that binds
with high affinity to nascent poly(A) tails. The protein is
required for progressive and efficient polymerization of poly(A)
tails on the 3' ends of eukaryotic genes and controls the size of
the poly(A) tail to about 250 nt. At steady-state, this protein is
localized in the nucleus whereas a different poly(A) binding
protein is localized in the cytoplasm. An expansion of the
trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end of
the coding region of this gene leads to autosomal dominant
oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice
variants have been described but their full-length nature is not
known. One splice variant includes introns 1 and 6 but no protein
is formed.
Background References:
- Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
- Hurt, J.A., et al. J. Cell Biol. 185(2):265-277(2009)
- Kuo, H.C., et al. J. Neurol. Sci. 278 (1-2), 21-24 (2009) :
- Tavanez, J.P., et al. PLoS ONE(7), E6418 (2009) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This PABPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-298 amino acids from the C-terminal region of human PABPN1.
NCBI Gene ID #:
8106
NCBI Official Name:
Polyadenylate-binding protein 2
NCBI Official Symbol:
PABPN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
33 kDa
Protein Accession #:
Q86U42
Protein GI Number:
46403176
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q86U42
User NOte:
Optimal dilutions for each application to be determined by the researcher.