FGD4 Antibody
| Code | Size | Price |
|---|
| PSI-56-777-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
FYVE, RhoGEF and PH domain-containing protein 4, Actin filament-binding protein frabin, FGD1-related F-actin-binding protein, Zinc finger FYVE domain-containing protein 6, FGD4, FRABP, ZFYVE6
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq].
Background References:
- Rose, J. Phd, et al. Mol. Med. (2010) In pressFabrizi, G.M., et al. Neurology 72(13):1160-1164(2009) Houlden, H., et al. Neurology 72(7):617-620(2009) Horlock, C., et al. Int. Arch. Allergy Immunol. 150(3):237-251(2009) Stendel, C., et al. Am. J. Hum. Genet. 81(1):158-164(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FGD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-186 amino acids from the N-terminal region of human FGD4.
NCBI Gene ID #:
121512
NCBI Official Name:
FYVE, RhoGEF and PH domain-containing protein 4
NCBI Official Symbol:
FGD4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
87 kDa
Protein Accession #:
Q96M96
Protein GI Number:
116241363
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q96M96
User NOte:
Optimal dilutions for each application to be determined by the researcher.