PNKP Antibody
| Code | Size | Price |
|---|
| PSI-57-487-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Bifunctional polynucleotide phosphatase/kinase, DNA 5'-kinase/3'-phosphatase, Polynucleotide kinase-3'-phosphatase, Polynucleotide 3'-phosphatase, 2'(3')-polynucleotidase, Polynucleotide 5'-hydroxyl-kinase, PNKP
Application Note:
For WB starting dilution is: 1:1000
Background:
This locus represents a gene involved in DNA repair. In
response to ionizing radiation or oxidative damage, the protein
encoded by this locus catalyzes 5' phosphorylation and 3'
dephosphorylation of nucleic acids. Mutations at this locus have
been associated with microcephaly, seizures, and developmental
delay.
Background References:
- Arora, M., et al. Leukemia 24(8):1470-1475(2010)
- Thyagarajan, B., et al. Biol. Blood Marrow Transplant. 16(8):1084-1089(2010)
- Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)
- Shen, J., et al. Nat. Genet. 42(3):245-249(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PNKP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the N-terminal region of human PNKP.
NCBI Gene ID #:
11284
NCBI Official Name:
Bifunctional polynucleotide phosphatase/kinase
NCBI Official Symbol:
PNKP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Protein Accession #:
Q96T60
Protein GI Number:
50401132
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q96T60
User NOte:
Optimal dilutions for each application to be determined by the researcher.