MCM8 Antibody
| Code | Size | Price |
|---|
| PSI-59-179-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA helicase MCM8, Minichromosome maintenance 8, MCM8, C20orf154
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is one of the highly
conserved mini-chromosome maintenance proteins (MCM) that are
essential for the initiation of eukaryotic genome replication. The
hexameric protein complex formed by the MCM proteins is a key
component of the pre-replication complex (pre_RC) and may be
involved in the formation of replication forks and in the
recruitment of other DNA replication related proteins. This protein
contains the central domain that is conserved among the MCM
proteins. This protein has been shown to co-immunoprecipitate with
MCM4, 6 and 7, which suggests that it may interact with other MCM
proteins and play a role in DNA replication. Alternatively spliced
transcript variants encoding distinct isoforms have been described.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Pelak, K., et al. J. Infect. Dis. 201(8):1141-1149(2010)
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- He, C., et al. Nat. Genet. 41(6):724-728(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MCM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-350 amino acids from the Central region of human MCM8.
NCBI Gene ID #:
84515
NCBI Official Name:
DNA helicase MCM8
NCBI Official Symbol:
MCM8
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
94 kDa
Protein Accession #:
Q9UJA3
Protein GI Number:
27805609
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9UJA3
User NOte:
Optimal dilutions for each application to be determined by the researcher.