ORC2L Antibody
| Code | Size | Price |
|---|
| PSI-57-767-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Origin recognition complex subunit 2, ORC2, ORC2L
Application Note:
For WB starting dilution is: 1:1000
Background:
The origin recognition complex (ORC) is a highly conserved
six subunits protein complex essential for the initiation of the
DNA replication in eukaryotic cells. Studies in yeast demonstrated
that ORC binds specifically to origins of replication and serves as
a platform for the assembly of additional initiation factors such
as Cdc6 and Mcm proteins. The protein encoded by this gene is a
subunit of the ORC complex. This protein forms a core complex with
ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are
proteins known to be important for the initiation of DNA
replication. This protein has been demonstrated to specifically
associate with the origin of replication of Epstein-Barr virus in
human cells, and is thought to be required for DNA replication from
viral origin of replication. Alternatively spliced transcript
variants have been found, one of which is a nonsense-mediated mRNA
decay candidate.
Background References:
- Huen, M.S., et al. Cell 131(5):901-914(2007)
- Siddiqui, K., et al. J. Biol. Chem. 282(44):32370-32383(2007)
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
- Radichev, I., et al. J. Biol. Chem. 281(32):23264-23273(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ORC2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human ORC2L.
NCBI Gene ID #:
4999
NCBI Official Name:
Origin recognition complex subunit 2
NCBI Official Symbol:
ORC2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
66 kDa
Protein Accession #:
Q13416
Protein GI Number:
8488999
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q13416
User NOte:
Optimal dilutions for each application to be determined by the researcher.