PABPC4 Antibody
| Code | Size | Price |
|---|
| PSI-59-056-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Polyadenylate-binding protein 4, PABP-4, Poly(A)-binding protein 4, Activated-platelet protein 1, APP-1, Inducible poly(A)-binding protein, iPABP, PABPC4, APP1, PABP4
Application Note:
For WB starting dilution is: 1:1000
Background:
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail
present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or
IPABP (inducible PABP) was isolated as an activation-induced T-cell
mRNA encoding a protein. Activation of T cells increased PABPC4
mRNA levels in T cells approximately 5-fold. PABPC4 contains 4
RNA-binding domains and proline-rich C terminus. PABPC4 is
localized primarily to the cytoplasm. It is suggested that PABPC4
might be necessary for regulation of stability of labile mRNA
species in activated T cells. PABPC4 was also identified as an
antigen, APP1 (activated-platelet protein-1), expressed on
thrombin-activated rabbit platelets. PABPC4 may also be involved in
the regulation of protein translation in platelets and
megakaryocytes or may participate in the binding or stabilization
of polyadenylates in platelet dense granules. Alternatively spliced
transcript variants encoding different isoforms have been found for
this gene.
Background References:
- Jonson, L., et al. Mol. Cell Proteomics 6(5):798-811(2007)
- Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
- Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PABPC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219-247 amino acids from the Central region of human PABPC4.
NCBI Gene ID #:
8761
NCBI Official Name:
Polyadenylate-binding protein 4
NCBI Official Symbol:
PABPC4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
71 kDa
Protein Accession #:
Q13310
Protein GI Number:
12229875
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q13310
User NOte:
Optimal dilutions for each application to be determined by the researcher.