PTBP1 Antibody
| Code | Size | Price |
|---|
| PSI-60-675-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Polypyrimidine tract-binding protein 1, PTB, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, hnRNP I, PTBP1, PTB
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene belongs to the subfamily of ubiquitously
expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
hnRNPs are RNA-binding proteins and they complex with heterogeneous
nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs
in the nucleus and appear to influence pre-mRNA processing and
other aspects of mRNA metabolism and transport. While all of the
hnRNPs are present in the nucleus, some seem to shuttle between the
nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic
acid binding properties. The protein encoded by this gene has four
repeats of quasi-RNA recognition motif (RRM) domains that bind
RNAs. This protein binds to the intronic polypyrimidine tracts that
requires pre-mRNA splicing and acts via the protein degradation
ubiquitin-proteasome pathway. It may also promote the binding of U2
snRNP to pre-mRNAs. This protein is localized in the nucleoplasm
and it is also detected in the perinucleolar structure.
Alternatively spliced transcript variants encoding different
isoforms have been described.
Background References:
- Kanda, T., et al. J. Viral Hepat. 17(9):618-623(2010)
- Cobbold, L.C., et al. Oncogene 29(19):2884-2891(2010)
- Verma, B., et al. J. Gen. Virol. 91 (PT 5), 1245-1255 (2010) :
- Maynard, C.M., et al. J. Mol. Biol. 397(1):260-277(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This PTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human PTBP1.
NCBI Gene ID #:
5725
NCBI Official Name:
Polypyrimidine tract-binding protein 1
NCBI Official Symbol:
PTBP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Protein Accession #:
P26599
Protein GI Number:
131528
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P26599
User NOte:
Optimal dilutions for each application to be determined by the researcher.