CHD1L Antibody

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ProSci
Product Code: PSI-58-475
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-58-475-400ul400ul£626.00
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in HepG2 cell line lysates (35ug/lane).
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Western blot analysis in HepG2 cell line lysates (35ug/lane).

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Further Information

Additional Names:
Chromodomain-helicase-DNA-binding protein 1-like, Amplified in liver cancer protein 1, CHD1L, ALC1
Application Note:
For WB starting dilution is: 1:1000
Background:
In response to DNA strand breaks, chromatin adopts a relaxed structure due to the addition of poly(ADP-ribose) (PAR) to chromatin proteins by PARP enzymes (see PARP1; MIM 173870), and this relaxation facilitates the repair of DNA damage. CHD1L interacts with PAR and has a role in chromatin relaxation following DNA damage (Ahel et al., 2009 [PubMed 19661379]).[supplied by OMIM].
Background References:
  • Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
  • Chen, L., et al. J. Clin. Invest. 120(4):1178-1191(2010)
  • Ahel, D., et al. Science 325(5945):1240-1243(2009)
  • Gottschalk, A.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(33):13770-13774(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CHD1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-590 amino acids from the Central region of human CHD1L.
NCBI Gene ID #:
9557
NCBI Official Name:
Chromodomain-helicase-DNA-binding protein 1-like
NCBI Official Symbol:
CHD1L
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
101 kDa
Protein Accession #:
Q86WJ1
Protein GI Number:
311033359
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q86WJ1
User NOte:
Optimal dilutions for each application to be determined by the researcher.