JPH2 Antibody

ProSci
Product Code: PSI-57-048
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-57-048-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).

Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).

Further Information

Additional Names:
Junctophilin-2, JP-2, Junctophilin type 2, JPH2, JP2
Application Note:
For WB starting dilution is: 1:1000
Background:
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.
Background References:
  • Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
  • Woo, J.S., et al. Biochem. J. 427(1):125-134(2010)
  • Yamazaki, D., et al. Pharmacol. Ther. 121(3):265-272(2009)
  • Landstrom, A.P., et al. J. Mol. Cell. Cardiol. 42(6):1026-1035(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This JPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-643 amino acids from the C-terminal region of human JPH2.
NCBI Gene ID #:
57158
NCBI Official Name:
Junctophilin-2
NCBI Official Symbol:
JPH2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
74 kDa
Protein Accession #:
Q9BR39
Protein GI Number:
27805486
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9BR39
User NOte:
Optimal dilutions for each application to be determined by the researcher.