CPSF3 Antibody

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ProSci
Product Code: PSI-58-002
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-58-002-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in A375 cell line lysates (35ug/lane).
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Western blot analysis in A375 cell line lysates (35ug/lane).

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Further Information

Additional Names:
Cleavage and polyadenylation specificity factor subunit 3, 3127-, Cleavage and polyadenylation specificity factor 73 kDa subunit, CPSF 73 kDa subunit, mRNA 3'-end-processing endonuclease CPSF-73, CPSF3, CPSF73
Application Note:
For WB starting dilution is: 1:1000
Background:
Most eukaryotic mRNA precursors (pre-mRNAs) undergo extensive maturational processing, including cleavage and polyadenylation at the 3-prime end. CPSF3 encodes the 73-kD subunit of the cleavage and polyadenylation specificity factor (CPSF) and is the pre-mRNA 3-prime-end-processing endonuclease (Mandel et al., 2006 [PubMed 17128255]).
Background References:
  • Rozenblatt-Rosen, O., et al. Proc. Natl. Acad. Sci. U.S.A. 106(3):755-760(2009)
  • Zhu, Z.H., et al. Oncogene 28(1):41-51(2009)
  • Yang, X.C., et al. Mol. Cell. Biol. 29(1):31-42(2009)
  • Kolev, N.G., et al. EMBO Rep. 9(10):1013-1018(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This CPSF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-221 amino acids from the Central region of human CPSF3.
NCBI Gene ID #:
51692
NCBI Official Name:
Cleavage and polyadenylation specificity factor subunit 3
NCBI Official Symbol:
CPSF3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
77 kDa
Protein Accession #:
Q9UKF6
Protein GI Number:
18203503
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9UKF6
User NOte:
Optimal dilutions for each application to be determined by the researcher.