UPF2 Antibody
| Code | Size | Price |
|---|
| PSI-55-346-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Regulator of nonsense transcripts 2, Nonsense mRNA reducing factor 2, Up-frameshift suppressor 2 homolog, hUpf2, UPF2, KIAA1408, RENT2
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
UPF2 is a protein that is part of a
post-splicing multiprotein complex involved in both mRNA nuclear
export and mRNA surveillance. mRNA surveillance detects exported
mRNAs with truncated open reading frames and initiates
nonsense-mediated mRNA decay (NMD). When translation ends upstream
from the last exon-exon junction, this triggers NMD to degrade
mRNAs containing premature stop codons. This protein is located in
the perinuclear area. It interacts with translation release factors
and the proteins that are functional homologs of yeast Upf1p and
Upf3p.
Background References:
- Clerici, M., et al. EMBO J. 28(15):2293-2306(2009)
- Cronin, S., et al. Eur. J. Hum. Genet. 17(2):213-218(2009)
- Woeller, C.F., et al. EMBO Rep. 9(5):446-451(2008)
- Chamieh, H., et al. Nat. Struct. Mol. Biol. 15(1):85-93(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This UPF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 630-656 amino acids from the Central region of human UPF2.
NCBI Gene ID #:
26019
NCBI Official Name:
Regulator of nonsense transcripts 2
NCBI Official Symbol:
UPF2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
148 kDa
Protein Accession #:
Q9HAU5
Protein GI Number:
60390647
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9HAU5
User NOte:
Optimal dilutions for each application to be determined by the researcher.