PUS1 Antibody
| Code | Size | Price |
|---|
| PSI-56-681-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
tRNA pseudouridine synthase A, mitochondrial, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I, PUS1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a pseudouridine synthase that converts
uridine to pseudouridine once it has been incorporated into an RNA
molecule. The encoded enzyme may play an essential role in tRNA
function and in stabilizing the secondary and tertiary structure of
many RNAs. A mutation in this gene has been linked to mitochondrial
myopathy and sideroblastic anemia. Alternate splicing results in
multiple transcript variants.
Background References:
- Bergmann, A.K., et al. Pediatr Blood Cancer 54(2):273-278(2010)
- Sibert, B.S., et al. RNA 14(9):1895-1906(2008)
- Rikova, K., et al. Cell 131(6):1190-1203(2007)
- Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PUS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-350 amino acids from the C-terminal region of human PUS1.
NCBI Gene ID #:
80324
NCBI Official Name:
tRNA pseudouridine synthase A, mitochondrial
NCBI Official Symbol:
PUS1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
Protein Accession #:
Q9Y606
Protein GI Number:
114152895
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9Y606
User NOte:
Optimal dilutions for each application to be determined by the researcher.