GGCX Antibody
| Code | Size | Price |
|---|
| PSI-55-643-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Vitamin K-dependent gamma-carboxylase, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase, GGCX, GC
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IHC-P starting dilution is: 1:50~100
Background:
This gene encodes an enzyme which catalyzes the
posttranslational modification of vitamin K-dependent protein. Many
of these vitamin K-dependent proteins are involved in coagulation
so the function of the encoded enzyme is essential for hemostasis.
Mutations in this gene are associated with vitamin K-dependent
coagulation defect and PXE-like disorder with multiple coagulation
factor deficiency. Multiple transcript variants encoding different
isoforms have been found for this gene.
Background References:
- Higgins-Gruber, S.L., et al. J. Biol. Chem. 285(41):31502-31508(2010)
- King, C.R., et al. Thromb. Haemost. 104(4):750-754(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Ikejiri, M., et al. Int. J. Hematol. 92(2):302-305(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This GGCX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-578 amino acids from the Central region of human GGCX.
NCBI Gene ID #:
2677
NCBI Official Name:
Vitamin K-dependent gamma-carboxylase
NCBI Official Symbol:
GGCX
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
88 kDa
Protein Accession #:
P38435
Protein GI Number:
84028279
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P38435
User NOte:
Optimal dilutions for each application to be determined by the researcher.