TPSD1 Antibody
| Code | Size | Price |
|---|
| PSI-55-222-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Tryptase delta, Delta-tryptase, HmMCP-3-like tryptase III, Mast cell mMCP-7-like, Tryptase-3, TPSD1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IHC-P starting dilution is: 1:50~100
Background:
Tryptases comprise a family of trypsin-like serine
proteases, the peptidase family S1. Tryptases are enzymatically
active only as heparin-stabilized tetramers, and they are resistant
to all known endogenous proteinase inhibitors. Several tryptase
genes are clustered on chromosome 16p13.3. These genes are
characterized by several distinct features. They have a highly
conserved 3' UTR and contain tandem repeat sequences at the 5'
flank and 3' UTR which are thought to play a role in regulation of
the mRNA stability. Although this gene may be an exception, most of
the tryptase genes have an intron immediately upstream of the
initiator Met codon, which separates the site of transcription
initiation from protein coding sequence. This feature is
characteristic of tryptases but is unusual in other genes.
Tryptases have been implicated as mediators in the pathogenesis of
asthma and other allergic and inflammatory disorders. TPSD1 was
once considered to be a pseudogene, although it is now believed to
be a functional gene that encodes a protein.
Background References:
- Jackson, N.E., et al. J. Biol. Chem. 283(49):34178-34187(2008)
- Caughey, G.H. J. Allergy Clin. Immunol. 117(6):1411-1414(2006)
- Wang, H.W., et al. J. Immunol. 169(9):5145-5152(2002)
- Caughey, G.H. Mol. Immunol. 38 (16-18), 1353-1357 (2002) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TPSD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-193 amino acids from the C-terminal region of human TPSD1.
NCBI Gene ID #:
23430
NCBI Official Name:
Tryptase delta
NCBI Official Symbol:
TPSD1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
27 kDa
Protein Accession #:
Q9BZJ3
Protein GI Number:
239938722
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9BZJ3
User NOte:
Optimal dilutions for each application to be determined by the researcher.