H2AFZ Antibody
| Code | Size | Price |
|---|
| PSI-55-724-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Histone H2AZ, H2A/z, H2AFZ, H2AZ
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Histones are basic nuclear proteins that are responsible
for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
wrapped around a histone octamer composed of pairs of each of the
four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
further compacted through the interaction of a linker histone, H1,
with the DNA between the nucleosomes to form higher order chromatin
structures. This gene encodes a replication-independent member of
the histone H2A family that is distinct from other members of the
family. Studies in mice have shown that this particular histone is
required for embryonic development and indicate that lack of
functional histone H2A leads to embryonic lethality. [provided by
RefSeq].
Background References:
- Marques, M., et al. Epigenetics 5(4):267-272(2010)
- Svotelis, A., et al. Cell Cycle 9(2):364-370(2010)
- Thakar, A., et al. Biochemistry 48(46):10852-10857(2009)
- Hardy, S., et al. PLoS Genet.(10), E1000687 (2009) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, C. Elegans, Chicken, Zebrafish, Drosophila, Mouse, Rabbit, Xenopus, Rat
Immunogen:
This H2AFZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-86 amino acids from the C-terminal region of human H2AFZ.
NCBI Gene ID #:
3015
NCBI Official Name:
Histone H2A.Z
NCBI Official Symbol:
H2AFZ
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
14 kDa
Protein Accession #:
P0C0S5
Protein GI Number:
83288408
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P0C0S5
User NOte:
Optimal dilutions for each application to be determined by the researcher.