IBTK Antibody
| Code | Size | Price |
|---|
| PSI-55-375-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Inhibitor of Bruton tyrosine kinase, IBtk, IBTK, BTKI, KIAA1417
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Background:
The protein encoded by this gene binds to Bruton's
tyrosine kinase (BTK) and downregulates BTK's kinase activity. In
addition, the encoded protein disrupts BTK-mediated calcium
mobilization and negatively regulates the activation of nuclear
factor-kappa-B-driven transcription.
Background References:
- Fiume, G., et al. Comput Biol Chem 33(6):434-439(2009)
- Spatuzza, C., et al. Nucleic Acids Res. 36(13):4402-4416(2008)
- Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-613 amino acids from the Central region of human IBTK.
NCBI Gene ID #:
25998
NCBI Official Name:
Inhibitor of Bruton tyrosine kinase
NCBI Official Symbol:
IBTK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
151 kDa
Protein Accession #:
Q9P2D0
Protein GI Number:
134034141
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9P2D0
User NOte:
Optimal dilutions for each application to be determined by the researcher.