PROC Antibody

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ProSci
Product Code: PSI-57-108
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-57-108-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western Blot at 1:500-1:1000 dilution Lane 1: human liver lysate Lane 2: human plasma lysate Lysates/proteins at 20 ug per lane.
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Confocal immunofluorescent analysis of PROC Antibody with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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Western Blot at 1:500-1:1000 dilution Lane 1: human liver lysate Lane 2: human plasma lysate Lysates/proteins at 20 ug per lane.
Confocal immunofluorescent analysis of PROC Antibody with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Documents

Further Information

Additional Names:
Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C light chain, Vitamin K-dependent protein C heavy chain, Activation peptide, PROC
Application Note:
For WB starting dilution is: 1:500-1:1000

For IF starting dilution is: 1:10~50

For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
Background References:
  • Tang, W., et al. Blood (2010) In press :
  • Agapkina, Iu.V., et al. Mol. Biol. (Mosk.) 44(4):613-619(2010)
  • Witt, I., et al. Blood Coagul. Fibrinolysis 5(4):651-653(1994)
  • Zhang, L., et al. Blood 80(4):942-952(1992)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PROC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 amino acids from the Central region of human PROC.
NCBI Gene ID #:
5624
NCBI Official Name:
Vitamin K-dependent protein C
NCBI Official Symbol:
PROC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
52 kDa
Protein Accession #:
P04070
Protein GI Number:
131067
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P04070
User NOte:
Optimal dilutions for each application to be determined by the researcher.