C2 Antibody
| Code | Size | Price |
|---|
| PSI-55-321-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Hamster
- Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Complement C2, C3/C5 convertase, Complement C2b fragment, Complement C2a fragment, C2
Application Note:
For WB starting dilution is: 1:1000
Background:
Component C2 is a serum glycoprotein that functions as
part of the classical pathway of the complement system. Activated
C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then
combines with complement factor 4b to create the C3 or C5
convertase. Deficiency of C2 has been reported to associated with
certain autoimmune diseases and SNPs in this gene have been
associated with altered susceptibility to age-related macular
degeneration. This gene localizes within the class III region of
the MHC on the short arm of chromosome 6. Alternative splicing
results in multiple transcript variants encoding distinct isoforms.
Additional transcript variants have been described in publications
but their full-length sequence has not been determined.
Background References:
- Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Liu, X., et al. Retina (Philadelphia, Pa.) 30(8):1177-1184(2010)
- Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the N-terminal region of human C2.
NCBI Gene ID #:
717
NCBI Official Name:
Complement C2
NCBI Official Symbol:
C2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
83 kDa
Protein Accession #:
P06681
Protein GI Number:
3915642
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
P06681
User NOte:
Optimal dilutions for each application to be determined by the researcher.