ERCC1 Antibody
| Code | Size | Price |
|---|
| PSI-57-479-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA excision repair protein ERCC-1, ERCC1
Application Note:
For WB starting dilution is: 1:1000
Background:
The product of this gene functions in the nucleotide
excision repair pathway, and is required for the repair of DNA
lesions such as those induced by UV light or formed by
electrophilic compounds including cisplatin. The encoded protein
forms a heterodimer with the XPF endonuclease (also known as
ERCC4), and the heterodimeric endonuclease catalyzes the 5'
incision in the process of excising the DNA lesion. The
heterodimeric endonuclease is also involved in recombinational DNA
repair and in the repair of inter-strand crosslinks. Mutations in
this gene result in cerebrooculofacioskeletal syndrome, and
polymorphisms that alter expression of this gene may play a role in
carcinogenesis. Multiple transcript variants encoding different
isoforms have been found for this gene. The last exon of this gene
overlaps with the CD3e molecule, epsilon associated protein gene on
the opposite strand.
Background References:
- Palli, D., et al. Mutagenesis 25(6):569-575(2010)
- Scheil-Bertram, S., et al. Gynecol. Oncol. 119(2):325-331(2010)
- Wenchao, L., et al. Diagn. Mol. Pathol. 19(3):164-168(2010)
- Hoffmann, A.C., et al. Neoplasia 12(8):628-636(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ERCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-297 amino acids from the C-terminal region of human ERCC1.
NCBI Gene ID #:
2067
NCBI Official Name:
DNA excision repair protein ERCC-1
NCBI Official Symbol:
ERCC1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
33 kDa
Protein Accession #:
P07992
Protein GI Number:
119538
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer
Swissprot #:
P07992
User NOte:
Optimal dilutions for each application to be determined by the researcher.