CDKN2C Antibody
Code | Size | Price |
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PSI-55-525-400ul | 400ul | £626.00 |
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Cyclin-dependent kinase 4 inhibitor C, Cyclin-dependent kinase 6 inhibitor, p18-INK4c, p18-INK6, CDKN2C, CDKN6
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IHC-P starting dilution is: 1:50~100
Background:
The protein encoded by this gene is a member of the INK4
family of cyclin-dependent kinase inhibitors. This protein has been
shown to interact with CDK4 or CDK6, and prevent the activation of
the CDK kinases, thus function as a cell growth regulator that
controls cell cycle G1 progression. Ectopic expression of this gene
was shown to suppress the growth of human cells in a manner that
appears to correlate with the presence of a wild-type RB1 function.
Studies in the knockout mice suggested the roles of this gene in
regulating spermatogenesis, as well as in suppressing
tumorigenesis. Two alternatively spliced transcript variants of
this gene, which encode an identical protein, have been reported.
Background References:
- Stratakis, C., et al. Clin. Genet. 78(5):457-463(2010)
- Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)
- Eguchi, T., et al. Mol. Cancer Ther. 8(6):1460-1472(2009)
- Pei, X.H., et al. Cancer Cell 15(5):389-401(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CDKN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-139 amino acids from the C-terminal region of human CDKN2C.
NCBI Gene ID #:
1031
NCBI Official Name:
Cyclin-dependent kinase 4 inhibitor C
NCBI Official Symbol:
CDKN2C
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
18 kDa
Protein Accession #:
P42773
Protein GI Number:
1168870
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle
Swissprot #:
P42773
User NOte:
Optimal dilutions for each application to be determined by the researcher.