TRAF1 Antibody
| Code | Size | Price |
|---|
| PSI-57-370-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
TNF receptor-associated factor 1, Epstein-Barr virus-induced protein 6, TRAF1, EBI6
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a member of the TNF
receptor (TNFR) associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from
various receptors of the TNFR superfamily. This protein and TRAF2
form a heterodimeric complex, which is required for
TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF2 also interacts
with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the
anti-apoptotic signals from TNF receptors. The expression of this
protein can be induced by Epstein-Barr virus (EBV). EBV infection
membrane protein 1 (LMP1) is found to interact with this and other
TRAF proteins; this interaction is thought to link LMP1-mediated B
lymphocyte transformation to the signal transduction from TNFR
family receptors. Three transcript variants encoding two different
isoforms have been found for this gene.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)
- Stahl, E.A., et al. Nat. Genet. 42(6):508-514(2010)
- Tan, R.J., et al. Ann. Rheum. Dis. 69(6):1029-1035(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TRAF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human TRAF1.
NCBI Gene ID #:
7185
NCBI Official Name:
TNF receptor-associated factor 1
NCBI Official Symbol:
TRAF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
46 kDa
Protein Accession #:
Q13077
Protein GI Number:
6707734
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
Q13077
User NOte:
Optimal dilutions for each application to be determined by the researcher.