RASSF1 Antibody
| Code | Size | Price |
|---|
| PSI-59-495-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Ras association domain-containing protein 1, RASSF1 {ECO:0000312|EMBL:AAF351282}
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a protein similar to the RAS effector
proteins. Loss or altered expression of this gene has been
associated with the pathogenesis of a variety of cancers, which
suggests the tumor suppressor function of this gene. The
inactivation of this gene was found to be correlated with the
hypermethylation of its CpG-island promoter region. The encoded
protein was found to interact with DNA repair protein XPA. The
protein was also shown to inhibit the accumulation of cyclin D1,
and thus induce cell cycle arrest. Seven alternatively spliced
transcript variants of this gene encoding distinct isoforms have
been reported.
Background References:
- El-Kalla, M., et al. Oncogene 29(42):5729-5740(2010)
- Vardi, A., et al. In Vivo 24(4):393-400(2010)
- Kim, J.H., et al. Virchows Arch. 457(1):35-42(2010)
- Ahmed, I.A., et al. Cancer Genet. Cytogenet. 199(2):96-100(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RASSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the Central region of human RASSF1.
NCBI Gene ID #:
11186
NCBI Official Name:
Ras association domain-containing protein 1
NCBI Official Symbol:
RASSF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
39 kDa
Protein Accession #:
Q9NS23
Protein GI Number:
50401686
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
Q9NS23
User NOte:
Optimal dilutions for each application to be determined by the researcher.