Metabotropic Glutamate Receptor 5 Antibody
| Code | Size | Price |
|---|
| PSI-62-258-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Metabotropic glutamate receptor 5, mGluR5, GRM5, GPRC1E, MGLUR5
Application Note:
For WB starting dilution is: 1:1000
Background:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 (also known as GPRC1E) and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM5 is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.
Background References:
- Pacheco, R., et al., J. Biol. Chem. 279(32):33352-33358 (2004).
- Anneser, J.M., et al., Neuroreport 15(2):271-273 (2004).
- Uchino, M., et al., J. Biol. Chem. 279(3):2254-2261 (2004).
- Corti, C., et al., J. Biol. Chem. 278(35):33105-33119 (2003).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Metabotropic Glutamate Receptor 5 (GPRC1E) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1020-1050 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 5 (GPRC1E).
NCBI Gene ID #:
2915
NCBI Official Name:
Metabotropic glutamate receptor 5
NCBI Official Symbol:
GRM5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
132 kDa
Protein Accession #:
P41594
Protein GI Number:
1709020
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Neuroscience,Signal Transduction,Growth Factor
Swissprot #:
P41594
User NOte:
Optimal dilutions for each application to be determined by the researcher.