COX7A2L Antibody
| Code | Size | Price |
|---|
| PSI-56-357-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Cytochrome c oxidase subunit 7A-related protein, mitochondrial, COX7a-related protein, Cytochrome c oxidase subunit VIIa-related protein, EB1, COX7A2L, COX7AR, COX7RP
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Cytochrome c oxidase (COX), the terminal component of the
mitochondrial respiratory chain, catalyzes the electron transfer
from reduced cytochrome c to oxygen. This component is a
heteromeric complex consisting of 3 catalytic subunits encoded by
mitochondrial genes and multiple structural subunits encoded by
nuclear genes. The mitochondrially-encoded subunits function in
electron transfer, and the nuclear-encoded subunits may function in
the regulation and assembly of the complex. This nuclear gene
encodes a protein similar to polypeptides 1 and 2 of subunit VIIa
in the C-terminal region, and also highly similar to the mouse
Sig81 protein sequence. This gene is expressed in all tissues, and
upregulated in a breast cancer cell line after estrogen treatment.
It is possible that this gene represents a regulatory subunit of
COX and mediates the higher level of energy production in target
cells by estrogen.
Background References:
- Fornuskova, D., et al. Biochem. J. 428(3):363-374(2010)
- Wheeler, H.E., et al. PLoS Genet.(10), E1000685 (2009) :
- Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)
- Schmidt, T.R., et al. J. Mol. Evol. 57(2):222-228(2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This COX7A2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the Central region of human COX7A2L.
NCBI Gene ID #:
9167
NCBI Official Name:
Cytochrome c oxidase subunit 7A-related protein, mitochondrial
NCBI Official Symbol:
COX7A2L
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
13 kDa
Protein Accession #:
O14548
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
O14548
User NOte:
Optimal dilutions for each application to be determined by the researcher.