CROT Antibody
| Code | Size | Price |
|---|
| PSI-63-919-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Peroxisomal carnitine O-octanoyltransferase, COT, CROT, COT
Application Note:
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For WB starting dilution is: 1:1000
Background:
CROT encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.
Background References:
- Li, Y.L., et al. FEBS J. 276(1):303-314(2009)
- Morillas, M., et al. J. Biol. Chem. 277(13):11473-11480(2002)
- van der Leij, F.R., et al. Mol. Genet. Metab. 71 (1-2), 139-153 (2000) :
- Ferdinandusse, S., et al. Biochem. Biophys. Res. Commun. 263(1):213-218(1999)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CROT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-79 amino acids from the N-terminal region of human CROT.
NCBI Gene ID #:
54677
NCBI Official Name:
Peroxisomal carnitine O-octanoyltransferase
NCBI Official Symbol:
CROT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
70 kDa
Protein Accession #:
Q9UKG9
Protein GI Number:
48429265
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
Q9UKG9
User NOte:
Optimal dilutions for each application to be determined by the researcher.