RHOC Antibody
| Code | Size | Price |
|---|
| PSI-57-478-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Rho-related GTP-binding protein RhoC, Rho cDNA clone 9, h9, RHOC, ARH9, ARHC
Application Note:
For WB starting dilution is: 1:2000
Background:
This gene encodes a member of the Rho family of small
GTPases, which cycle between inactive GDP-bound and active
GTP-bound states and function as molecular switches in signal
transduction cascades. Rho proteins promote reorganization of the
actin cytoskeleton and regulate cell shape, attachment, and
motility. The protein encoded by this gene is prenylated at its
C-terminus, and localizes to the cytoplasm and plasma membrane. It
is thought to be important in cell locomotion. Overexpression of
this gene is associated with tumor cell proliferation and
metastasis. Multiple alternatively spliced variants, encoding the
same protein, have been identified.
Background References:
- Jiang, L., et al. Int. J. Cancer 127(3):505-512(2010)
- Wu, M., et al. Cancer 116 (11 SUPPL), 2768-2782 (2010) :
- Lipkin, S.M., et al. Cancer Prev Res (Phila) 3(5):597-603(2010)
- Kitzing, T.M., et al. Oncogene 29(16):2441-2448(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This RHOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human RHOC.
NCBI Gene ID #:
389
NCBI Official Name:
Rho-related GTP-binding protein RhoC
NCBI Official Symbol:
RHOC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
22 kDa
Protein Accession #:
P08134
Protein GI Number:
132543
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
P08134
User NOte:
Optimal dilutions for each application to be determined by the researcher.