IGFBP4 Antibody

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ProSci
Product Code: PSI-62-553
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-62-553-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in mouse lung tissue lysates (15ug/lane).This demonstrates the detected IGFBP4 protein (arrow).
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IGFBP4 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
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Western blot analysis in mouse lung tissue lysates (15ug/lane).This demonstrates the detected IGFBP4 protein (arrow).
IGFBP4 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.

Documents

Further Information

Additional Names:
Insulin-like growth factor-binding protein 4, IBP-4, IGF-binding protein 4, IGFBP-4, IGFBP4, IBP4
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50
Background:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
Background References:
  • Giroux, S., et al. Bone 47(5):975-981(2010)
  • Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
  • Bartling, B., et al. Int. J. Mol. Med. 25(1):89-96(2010)
  • Johnatty, S.E., et al. PLoS Genet.(7), E1001016 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Pig
Immunogen:
This IGFBP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of human IGFBP4.
NCBI Gene ID #:
3487
NCBI Official Name:
Insulin-like growth factor-binding protein 4
NCBI Official Symbol:
IGFBP4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
28 kDa
Protein Accession #:
P22692
Protein GI Number:
124065
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
P22692
User NOte:
Optimal dilutions for each application to be determined by the researcher.