NR3C1 Antibody
| Code | Size | Price |
|---|
| PSI-61-939-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
Background:
NR3C1 is a receptor for
glucocorticoids that can act as both a transcription factor and as
a regulator of other transcription factors. This protein can also
be found in heteromeric cytoplasmic complexes along with heat shock
factors and immunophilins. The protein is typically found in the
cytoplasm until it binds a ligand, which induces transport into the
nucleus. Mutations in this gene are a cause of glucocorticoid
resistance, or cortisol, resistance. Alternate splicing, the use of
at least three different promoters, and alternate translation
initiation sites result in several transcript variants encoding the
same protein or different isoforms, but the full-length nature of
some variants has not been determined.
Background References:
- Bosker, F.J., et al. Mol. Psychiatry (2010)
- Inkster, B., et al. Neuroimage (2010)
- Geelhoed, M.J., et al. BMC Med. Genet. 11, 39 (2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rb
Immunogen:
This NR3C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-262 amino acids from the Central region of human NR3C1.
NCBI Gene ID #:
2908
NCBI Official Name:
Glucocorticoid receptor
NCBI Official Symbol:
NR3C1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
86 kDa
Protein Accession #:
P04150
Protein GI Number:
121069
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
P04150
User NOte:
Optimal dilutions for each application to be determined by the researcher.